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Related Experiment Videos

Evidence for a circulating ergostatic factor: studies on parabiotic rats.

Y Nishizawa, G A Bray

    The American Journal of Physiology
    |September 1, 1980
    PubMed
    Summary

    Rats with ventromedial hypothalamic lesions or forced overfeeding showed altered body fat, suggesting a blood-borne energy stabilizing factor. This factor influences fatness and body density in both affected and unaffected parabiotic partners.

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    Area of Science:

    • Physiology
    • Endocrinology
    • Metabolism

    Background:

    • The ventromedial hypothalamus plays a role in regulating energy balance.
    • Parabiosis allows for the study of humoral factors influencing metabolic processes.

    Purpose of the Study:

    • To investigate the effects of ventromedial hypothalamic lesions and forced overfeeding on body composition in parabiotic rats.
    • To explore the existence of a blood-borne factor that regulates energy homeostasis.

    Main Methods:

    • Electrolytic lesions were induced in the ventromedial hypothalamus of one rat in a parabiotic pair.
    • Forced overfeeding with high-fat or high-carbohydrate diets was administered via gastric cannulas to one partner.
    • Body fat, body density, and oral caloric intake were measured in both lesioned/fed and unlesioned/unfed partners.

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    Main Results:

    • Ventromedial hypothalamic lesions led to increased fatness in the lesioned rat and decreased fatness in the unlesioned partner.
    • Forced overfeeding reduced oral intake and body fat in the non-tube-fed partner compared to controls.
    • These findings indicate a transfer of an energy-regulating signal between parabiotic partners.

    Conclusions:

    • A circulating ergostatic (energy stabilizing) factor appears to exist.
    • This factor is transported via the bloodstream and influences body fat regulation in a reciprocal manner between parabiotic rats.