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[Genetic restrictions of the HGG high-zone tolerance specific suppressive factor: arguments against a direct
Human gamma-globulin (HGG) high-dose tolerance spleen cell factor is shown to be genetically restricted. Yet, macrophages are not required for its production; and BALB/c mice, whose macrophages are hyperactive, can be tolerized partially by H-2d compatible factor or factor produced by BALB/c mice previously rendered sensitive to tolerance induction by carrageenan pretreatment. Thus, direct, involvement of macrophages in genetic restrictions appears unlikely. Since iron powder treatment unveils an amplifier effect of the crude supernatant from tolerant cells, it is suggested that specific and non-specific amplification coexists with suppression at day 5 of HGG-tolerance induction. Thus, interaction between an IJ+ suppressor T cell and an IJ+ amplifier cell or helper cell (or its precursor) is suggested to account for the observed genetic restrictions.
Human gamma-globulin (HGG) high-dose tolerance spleen cell factor is shown to be genetically restricted. Yet, macrophages are not required for its production; and BALB/c mice, whose macrophages are hyperactive, can be tolerized partially by H-2d compatible factor or factor produced by BALB/c mice previously rendered sensitive to tolerance induction by carrageenan pretreatment. Thus, direct, involvement of macrophages in genetic restrictions appears unlikely. Since iron powder treatment unveils an amplifier effect of the crude supernatant from tolerant cells, it is suggested that specific and non-specific amplification coexists with suppression at day 5 of HGG-tolerance induction. Thus, interaction between an IJ+ suppressor T cell and an IJ+ amplifier cell or helper cell (or its precursor) is suggested to account for the observed genetic restrictions.