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[Human gammaglobulin tolerance: shared idiotypy of T-cell suppressor factor and antibodies (author's transl)]
A factor from human gammaglobulin (HGG) high-zone-tolerant CBA splenic T cells has been produced in optimal conditions after a 16-h culture in CBA mice. A CBA anti-(CBA anti-HGG) serum, purified on HGG, and referred to as antiidiotypic serum, has been coupled to Sepharose-4B. The factor can be adsorbed by this antiidiotypic serum but to a smaller extent than by anti-Iak. The existence of shared idiotypic determinants by factor and antibodies is discussed.
A factor from human gammaglobulin (HGG) high-zone-tolerant CBA splenic T cells has been produced in optimal conditions after a 16-h culture in CBA mice. A CBA anti-(CBA anti-HGG) serum, purified on HGG, and referred to as antiidiotypic serum, has been coupled to Sepharose-4B. The factor can be adsorbed by this antiidiotypic serum but to a smaller extent than by anti-Iak. The existence of shared idiotypic determinants by factor and antibodies is discussed.