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Updated: Oct 11, 2026

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance
14:01

Human In Vitro Suppression as Screening Tool for the Recognition of an Early State of Immune Imbalance

Published on: July 22, 2011

[Human gammaglobulin tolerance: shared idiotypy of T-cell suppressor factor and antibodies (author's transl)]

G Chaouat

    Annales D'Immunologie
    |July 1, 1980
    PubMed

    A factor from human gammaglobulin (HGG) high-zone-tolerant CBA splenic T cells has been produced in optimal conditions after a 16-h culture in CBA mice. A CBA anti-(CBA anti-HGG) serum, purified on HGG, and referred to as antiidiotypic serum, has been coupled to Sepharose-4B. The factor can be adsorbed by this antiidiotypic serum but to a smaller extent than by anti-Iak. The existence of shared idiotypic determinants by factor and antibodies is discussed.

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