Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bleomycin-induced scleroderma.

W R Finch, G P Rodnan, R B Buckingham

    The Journal of Rheumatology
    |September 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The Natural History of Progressive Systemic Sclerosis (difuse Scleroderma).

    Indian journal of dermatology and venereology·2017
    Same author

    Relation of gastric acidity to recurrent ulcers after partial gastrectomy.

    The Journal of the International College of Surgeons·2010
    Same author

    The prophylaxis of peptic ulcer.

    Gastroenterology·2010
    Same author

    Modern treatment of gastric ulcer.

    Strasbourg medical·2010
    Same author

    The significance of the gastric acidity in the surgical therapy of peptic ulcer.

    The Surgical clinics of North America·2010
    Same author

    The Modern Treatment of Peptic Ulcer.

    Bulletin of the New York Academy of Medicine·2009
    Same journal

    Clinical Features and Outcome Measures Across Still Disease (Systemic Juvenile Idiopathic Arthritis and Adult-Onset Still Disease) Cohorts Worldwide: A Systematic Literature Review.

    The Journal of rheumatology·2026
    Same journal

    Concurrent Calcium Pyrophosphate Deposition Disease and Gout of the Cervical Spine Presenting With Subacute Neck Pain and Radiculopathy.

    The Journal of rheumatology·2026
    Same journal

    The Need for Weight Communication Guidelines in Pediatric Rheumatology.

    The Journal of rheumatology·2026
    Same journal

    Bimekizumab Improves Health Status and Work Productivity, With Reduced Productivity Costs, to 3 Years in Axial Spondyloarthritis and Psoriatic Arthritis.

    The Journal of rheumatology·2026
    Same journal

    Qualitative Analysis of Physical Activity Engagement in Women with Self-Reported SLE: The Role of Symptoms, Healthcare Providers, and the Environment.

    The Journal of rheumatology·2026
    Same journal

    Tumoral Calcinosis-like Calcification of the Proximal Interphalangeal Joint Mimicking Rheumatoid Arthritis Flare.

    The Journal of rheumatology·2026
    See all related articles

    Bleomycin, an antitumor drug, can cause skin fibrosis similar to scleroderma by increasing collagen production in skin cells. This effect may also contribute to other toxic reactions in the skin and lungs.

    Area of Science:

    • Dermatology
    • Oncology
    • Cell Biology

    Background:

    • Cutaneous fibrosis is a key feature of progressive systemic sclerosis (PSS, scleroderma).
    • Bleomycin is an antitumor agent with known toxicities.
    • The development of PSS-like skin changes after bleomycin treatment has been reported.

    Purpose of the Study:

    • To investigate the mechanism by which bleomycin may induce cutaneous fibrosis.
    • To examine the effect of bleomycin on collagen synthesis by dermal fibroblasts.
    • To assess the in vitro response of patient fibroblasts and normal fibroblasts to bleomycin.

    Main Methods:

    • Case report of two patients developing skin fibrosis after bleomycin therapy.
    • In vitro culture of dermal fibroblasts from one patient and normal controls.

    Related Experiment Videos

  • Assessment of collagen synthesis in cultured fibroblasts.
  • Evaluation of lymphoproliferative response to bleomycin in vitro.

    • Main Results:

    • Patient fibroblasts showed increased collagen synthesis in vitro, resembling PSS cells.
    • Bleomycin directly stimulated collagen production in normal skin fibroblasts.
    • Bleomycin induced a lymphoproliferative response in one patient's cells in vitro.
    • The observed effects suggest a mechanism for bleomycin-induced skin and lung toxicity.

    Conclusions:

    • Bleomycin can induce cutaneous fibrosis by stimulating collagen production in dermal fibroblasts.
    • These cellular effects may explain bleomycin's toxicity in the skin and lungs.
    • Further research is warranted to understand and mitigate these adverse drug reactions.