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[Histamine-release: present data and practical interest (author's transl)].

J Kofman, N Biot, M Perrin-Fayolle

    Le Poumon Et Le Coeur
    |January 1, 1980
    PubMed
    Summary
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    Histamine release from immune and mast cells is a key marker for hypersensitivity. A whole blood test can differentiate immune from irritative histamine release mechanisms for diagnosis.

    Area of Science:

    • Immunology
    • Pharmacology

    Context:

    • Histamine is a crucial mediator in hypersensitivity reactions.
    • Histamine is stored in basophils and mast cells and released by immune or irritant factors.
    • Understanding histamine release mechanisms is vital for diagnosing allergic and irritant-induced conditions.

    Purpose:

    • To detail the intricate mechanisms of histamine release.
    • To explain the regulatory pathways of histamine release, including cyclic nucleotides and H2 receptors.
    • To present a whole blood histamine release test for differentiating release mechanisms.

    Summary:

    • Histamine release involves receptor recognition, enzymatic cascades, calcium influx, mediator synthesis, and degranulation.
    • Immune-mediated release shows a bell-shaped dose-response curve, while irritant-induced release exhibits an ascending curve.

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  • The test aids in diagnosing drug allergies, occupational asthma, and evaluating drug pharmacology.

    • Impact:

    • Provides a diagnostic tool for hypersensitivity reactions.
    • Facilitates differentiation between immune and irritant-induced histamine release.
    • Supports the study of drug effects on histamine release pathways.