Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Substance P--new aspect to its modulatory function.

P Oehme, K Hecht, L Piesche

    Acta Biologica Et Medica Germanica
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Acetaminophen - A modern classic under suspicion].

    MMW Fortschritte der Medizin·2013
    Same author

    Textured biomaterials as a model for studying formation of focal contacts and rearrangement of the contractile cytoskeleton in platelets.

    Platelets·2010
    Same author

    [Biological rhythms and sleep rhythms].

    Aviakosmicheskaia i ekologicheskaia meditsina = Aerospace and environmental medicine·2008
    Same author

    Noise-induced annoyance and morbidity results from the pan-European LARES study.

    Noise & health·2007
    Same author

    High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis.

    Leukemia·2006
    Same author

    Expression of poliovirus receptor-related proteins PRR1 and PRR2 in acute myeloid leukemia: first report of surface marker analysis, contribution to diagnosis, prognosis and implications for future therapeutical strategies.

    European journal of haematology·2005

    Substance P (SP) modulates pain perception and behavior, standardizing responses and normalizing stress-induced disorders. SP also affects norepinephrine uptake in the hypothalamus, leading to its proposed classification as a "regulide".

    Area of Science:

    • Neuroscience
    • Pharmacology
    • Physiology

    Background:

    • Substance P (SP) is a neuropeptide involved in various physiological processes.
    • Its modulatory functions on nociperception, behavior, and neurotransmitter uptake require further elucidation.
    • Understanding SP's role is crucial for developing novel therapeutic strategies.

    Purpose of the Study:

    • To investigate the modulatory effects of Substance P (SP) on nociperception and behavior.
    • To examine SP's influence on norepinephrine uptake in hypothalamic preparations.
    • To propose a new classification for peptides with similar regulatory actions.

    Main Methods:

    • Utilized the hot-plate test to assess SP's effect on thermal stimuli response time in mice.
    • Evaluated SP's impact on noise-induced stress and avoidance reaction acquisition.

    Related Experiment Videos

  • Measured vegetative parameters including blood pressure, heart rate, and respiratory rate.
  • Assessed SP's effect on norepinephrine uptake in hypothalamic tissue under varying experimental conditions.

    • Main Results:

    • SP standardized individual response times to thermal stimuli in the hot-plate test.
    • SP normalized behavioral and vegetative disorders induced by noise-borne stress.
    • SP exhibited dual effects on norepinephrine uptake, either inhibiting or stimulating it based on experimental context.
    • The study identified SP's context-dependent modulatory actions.

    Conclusions:

    • Substance P (SP) demonstrates significant modulatory effects on pain perception, behavior, and physiological parameters.
    • SP's influence is dependent on the individual's baseline condition.
    • SP's capacity to regulate norepinephrine uptake suggests a broader role in neural function.
    • The findings support the proposal to classify SP and similar peptides as 'regulides'.