Substance P--new aspect to its modulatory function

The paper deals with a modulatory function of Substance P (SP) (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-MetNH2) with bearing on nociperception, behaviour, and norepinephrine uptake. The effect of SP on both nociperception and behaviour was found to depend on the original condition of the individuals. The individual response time of mice to thermic stimuli becomes standardized by Substance P in the hot-plate test. Disorders in acquisition of avoidance reactions caused by noiseborne stress were found to be fully normalized by SP, like certain vegetative parameters, such as blood pressure, heart rate, and respiratory rate. SP was found to inhibit or stimulate norepinephrine uptake of hypothalamus preparations depending on the experimental conditions. It is recommended to name peptides of the above type of action as "regulatory peptides" (regulides).