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Interferon as a model lymphokine.

L B Epstein

    Federation Proceedings
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Researchers reviewed interferon production and genetic control, finding immune interferon is produced by T lymphocytes. They located the human interferon response gene on chromosome 21 and the mouse gene on chromosome 16.

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    Area of Science:

    • Immunology
    • Genetics
    • Molecular Biology

    Background:

    • Interferons (IFNs) are crucial cytokines involved in immune responses.
    • Understanding the genetic control of IFN response is vital for disease research.
    • T lymphocytes play a significant role in producing and responding to IFNs.

    Purpose of the Study:

    • To review the production, action, and genetic control of response to interferon.
    • To investigate the effects of interferon on antiviral, antiproliferative, and differentiation processes.
    • To identify and map the genetic locus controlling interferon response in humans and mice.

    Main Methods:

    • Analysis of mitogen-stimulated T lymphocyte subsets (T mu, T gamma, T phi).
    • Investigation of interferon's biological effects (antiviral, antiproliferative, antidifferentiational).

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  • Genetic mapping of the interferon response locus using human chromosome 21 and mouse chromosome 16.

    • Main Results:

    • Human immune interferon is produced by specific T lymphocyte subsets.
    • Interferon exhibits antiviral, antiproliferative, and antidifferentiational effects.
    • The human interferon response locus is on chromosome 21; the mouse locus is on chromosome 16.

    Conclusions:

    • Imbalance in the chromosome 21 locus (e.g., trisomy 21) enhances cellular sensitivity to interferon.
    • Enhanced interferon sensitivity may contribute to immune abnormalities in conditions like Down syndrome.
    • The identified genetic loci provide targets for understanding and potentially treating immune-related disorders.