[Mechanism of silybin action, IV. Structure-action relationship (author's transl)]

In order to find out those structural elements of the flavonolignane silybin which are essential for its stimulatory effect on RNA synthesis, a series of flavonoids etc. has been tested for efficiency. Isolated liver cell nuclei in vitro and hepatocyte cultures have been used to follow RNA synthesis. Only a few compounds show effects similar to those of silybin. Possible structural parameters essential for stimulation are discussed.