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Related Experiment Videos

A new look at reticuloendothelial blockade.

J W Bradfield

    British Journal of Experimental Pathology
    |December 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Reticuloendothelial blockade was re-examined using organ uptake. Dextran sulfate selectively impaired liver phagocytosis, not spleen or bone marrow, making the term "blockade" inappropriate.

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    Area of Science:

    • Immunology
    • Pharmacology
    • Cell Biology

    Background:

    • The reticuloendothelial system (RES) plays a crucial role in clearing foreign particles from circulation.
    • Reticuloendothelial blockade is a term used to describe the phenomenon where the RES's phagocytic capacity is overwhelmed or impaired.
    • Previous studies often relied on blood clearance rates to assess RES function, potentially overlooking organ-specific effects.

    Purpose of the Study:

    • To re-evaluate the characteristics of reticuloendothelial blockade using organ uptake as the primary assessment method.
    • To investigate the specific organ distribution and phagocytic activity of macrophages following induction of blockade.
    • To determine the appropriateness of the term "reticuloendothelial blockade" based on experimental findings.

    Main Methods:

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    • Induction of blockade in mice using intravenous (i.v.) dextran sulfate.
    • Assessment of phagocytic activity using i.v. administration of 51Cr-labeled sheep red blood cells as test particles.
    • Quantification of particle uptake in various organs, including the liver, spleen, and bone marrow.

    Main Results:

    • Intravenous dextran sulfate selectively depressed hepatic phagocytosis.
    • Splenic and bone-marrow clearance of test particles remained unimpaired, indicating organ-specific effects.
    • The observed effects could be quantified across a wide range of test particle doses, without requiring saturating doses.

    Conclusions:

    • The term "reticuloendothelial blockade" is inappropriate due to the selective action of the blocking agent on hepatic phagocytosis.
    • Intravenous administration of test particles primarily assesses macrophages lining blood channels, limiting comprehensive RES evaluation.
    • Organ uptake measurements provide a more accurate assessment of RES function and the specific impact of interventions.