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Normal function of the thyroid gland in PUVA-treated psoriatics
Acta Dermato-Venereologica
|January 1, 1980
Summary
Psoralen plus long-wave ultraviolet radiation (PUVA) therapy did not significantly affect thyroid function in patients with psoriasis. Thyroid hormone levels (thyroxine, triiodothyronine, thyrotropin) remained stable during and after treatment.
Area of Science:
- Dermatology
- Endocrinology
- Phototherapy
Background:
- Psoriasis is a chronic autoimmune skin condition.
- Phototherapy, including PUVA, is a common treatment for psoriasis.
- Potential systemic effects of PUVA therapy require investigation.
Purpose of the Study:
- To evaluate the impact of psoralen plus long-wave ultraviolet radiation (PUVA) on thyroid gland function in patients with psoriasis.
Main Methods:
- Ten patients with psoriasis undergoing PUVA therapy were monitored.
- Serum levels of thyroxine, triiodothyronine, and thyrotropin were measured.
- Measurements were taken at 2 and 4 weeks during therapy and 3 months post-therapy.
Main Results:
- No statistically significant changes were observed in serum thyroxine levels.
- No statistically significant changes were observed in serum triiodothyronine levels.
- No statistically significant changes were observed in serum thyrotropin levels.
Conclusions:
- PUVA therapy does not appear to adversely affect thyroid gland function in patients with psoriasis.
- Thyroid hormone levels remain within normal ranges during and after PUVA treatment.
- Further long-term studies may be warranted to confirm these findings.