[Experiences with 31 anaphylactoid reactions (author's transl)].

Area of Science:

• Anesthesiology
• Pharmacology
• Critical Care Medicine

Background:

• Anaphylactoid reactions are serious adverse events associated with various medical agents.
• Prompt and effective management is crucial for patient survival and recovery.

Purpose of the Study:

• To report anaphylactoid reactions to Dextran, Propanidid, Althesin, Ampicillin, and Mepivacaine.
• To evaluate the efficacy of rapid fluid resuscitation, prednisolone, and epinephrine in managing these reactions.

Main Methods:

• Case reporting of anaphylactoid reactions.
• Rapid infusion of Ringer lactate and colloid solutions (2,000-3,000 ml).
• Administration of prednisolone and epinephrine for treatment.

Main Results:

• Circulation was restored within 30 minutes in patients receiving rapid fluid infusion.
• Prednisolone administration did not demonstrate positive therapeutic effects.
• Epinephrine administration resulted in more negative than positive effects in 3 out of 4 cases.

Conclusions:

• Rapid fluid resuscitation is an effective initial treatment for anaphylactoid reactions.
• The utility of prednisolone and epinephrine in this context requires further investigation and may be limited.