Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Abnormal serum alpha 2-macroglobulin in multiple sclerosis.

S C Rastogi, J Clausen, T Fog

    European Neurology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A review of analytical parameters in 'rapid' liquid chromatographic methods for bioanalysis: Can we do better?

    Journal of chromatography. A·2024
    Same author

    Adverse impact of a high CD4/CD8 ratio in the allograft may be overcome by methotrexate- but not mycophenolate- or post-transplant cyclophosphamide-based graft versus host disease prophylaxis.

    European journal of haematology·2023
    Same author

    Lesion topography of posterior cerebral artery infarcts.

    Journal of the neurological sciences·2021
    Same author

    On the convergence of projective-simulation-based reinforcement learning in Markov decision processes.

    Quantum machine intelligence·2020
    Same author

    A cross-sectional field study on potential associations between feed quality measures and usage of antimicrobials in commercial mink (Neovison vison).

    Preventive veterinary medicine·2017
    Same author

    Two-stage late reconstruction with a fresh large osteochondral shell allograft transplantation (FLOCSAT) for a large ostechondral defect in a non-union after a lateral tibia plateau fracture 2-year follow up.

    Injury·2017
    Same journal

    Combined Olfactory Testing and Substantia Nigra Hyperechogenicity for Diagnostic Differentiation of Parkinson's Disease.

    European neurology·2026
    Same journal

    The Role of Stroke Severity in the Association between Hypoperfusion Intensity Ratio and Futile Reperfusion after Endovascular Treatment.

    European neurology·2026
    Same journal

    The Parkinsonism of Salvador Dalí.

    European neurology·2026
    Same journal

    Disorders of Arousal and Sleep-Related Hypermotor Epilepsy in Adults: A Challenging but Necessary and Critical Distinctive Diagnosis.

    European neurology·2026
    Same journal

    Sex-Specific Phenotypic Characteristics in Obstructive Sleep Apnea: A Comprehensive Analysis of Anthropometric, Hematological, and Metabolic Profiles Stratified by Disease Severity.

    European neurology·2026
    Same journal

    Historical and Clinical Analysis of a Case of Progressive Muscular Atrophy (1853-1871).

    European neurology·2026
    See all related articles

    Serum alpha 2-macroglobulin (alpha 2-M) is abnormal in multiple sclerosis (MS) patients, presenting as asymmetric immunoprecipitates. This abnormality shows potential as a diagnostic marker for MS, with high accuracy in patient identification.

    Area of Science:

    • Neurology
    • Immunology
    • Biochemistry

    Background:

    • Serum alpha 2-macroglobulin (alpha 2-M) is a key protein in the immune system.
    • Previous studies suggest potential alterations in alpha 2-M in various neurological conditions.

    Purpose of the Study:

    • To investigate the electrophoretic properties of alpha 2-macroglobulin (alpha 2-M) in multiple sclerosis (MS) patients.
    • To assess the potential of alpha 2-M abnormalities as a diagnostic biomarker for MS.

    Main Methods:

    • Crossed immunoelectrophoresis (CI) was utilized to analyze serum samples.
    • Fifty coded serum samples from MS and non-MS patients were analyzed using CI.

    Main Results:

    • Abnormal alpha 2-M, characterized by asymmetric immunoprecipitates indicating different electrophoretic mobilities, was detected in 85% of MS patients.

    Related Experiment Videos

  • The CI method demonstrated a high diagnostic accuracy, with only 16% of non-MS patients misclassified.

    • Conclusions:

    • Abnormal alpha 2-M is a prevalent finding in multiple sclerosis patients.
    • Crossed immunoelectrophoresis of alpha 2-M shows promise as a diagnostic tool for MS, offering good specificity and sensitivity.