[Intracellular immunoglobulins in lymphogranulomatosis]

In 27 cases of malignant lymphogranulomatosis investigations were made on the intracellular presence of severe chains of immunoglobulins (IgM, IgG, IgA) in plasma cells and prestages of plasma cells or in atypical cells (Sternberg-Reed, mirror picture, and Hodgkin cells) by using the immunoperoxidase method. In 7 cases an intensive intracellular colouring of IgG could be observed, with immature prestages of plasma cells being present simultaneously (plasmoblasts, immunoblasts). In 16 cases IgG was slightly marked only, no plasma cells being present. With regard to the first group the development of atypical cells in these cases may be supposed to be connected with the presence of precursors of plasma cells.