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Rat ovarian mast cells: distribution and cyclic changes.

R E Jones, D Duvall, L J Guillette

    The Anatomical Record
    |August 1, 1980
    PubMed
    Summary
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    Rat ovarian mast cells degranulate during proestrus and regranulate during estrus, suggesting histamine secretion from these cells and blood vessels may influence ovarian function.

    Area of Science:

    • Reproductive biology
    • Histology
    • Cell biology

    Background:

    • Mast cells are abundant in rat ovarian medulla, hilus, and oviduct.
    • Medullary mast cells exhibit cyclic degranulation and regeneration during the estrous cycle.

    Purpose of the Study:

    • To investigate the presence and distribution of mast cells in the rat ovary and oviduct.
    • To determine the histamine content of these mast cells and associated blood vessels.
    • To explore the potential role of mast cell and blood vessel histamine in ovarian function.

    Main Methods:

    • Histochemical staining to identify and quantify mast cells.
    • Histofluorometric analysis to measure histamine levels.
    • Observation of mast cell degranulation and regeneration patterns throughout the estrous cycle.

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    Main Results:

    • Mast cells in the ovarian medulla undergo significant degranulation during proestrus and subsequent regeneration during estrus.
    • Mast cells in the ovarian hilus and oviduct do not show cyclic changes in number.
    • Histamine is present in mast cells of the ovarian medulla and hilus, and oviduct, as well as in the lining of ovarian medullary blood vessels.

    Conclusions:

    • Mast cell degranulation and histamine release in the ovarian medulla are linked to the estrous cycle.
    • Histamine secreted by mast cells and ovarian blood vessels may play a functional role in regulating ovarian activity.