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Related Experiment Videos

Multiple B cell stimulation by individual antigen-specific T lymphocytes.

S K Pierce, N R Klinman

    European Journal of Immunology
    |February 1, 1981
    PubMed
    Summary

    Individual T lymphocytes can help multiple B lymphocytes respond, even if those B cells recognize different antigens. This highlights the broad collaborative potential of antigen-specific T cells in initiating antibody production.

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    B-cell development.

    Immunology today·2014

    Area of Science:

    • Immunology
    • Cellular immunology

    Background:

    • Helper T lymphocytes are crucial for B lymphocyte activation and antibody production.
    • Previous systems limited the study of T-B cell interactions to single specificities.

    Purpose of the Study:

    • To investigate if a single T lymphocyte can interact with and help multiple B lymphocytes with differing antigen specificities.
    • To determine the collaborative potential of antigen-specific T cells in initiating B cell antibody responses.

    Main Methods:

    • Utilized an experimental system for isolating and stimulating individual antigen-specific helper T lymphocytes with B lymphocytes.
    • Employed in vitro antigen stimulation using specific T and B cell populations.

    Main Results:

    • An individual influenza virus PR 8-specific T lymphocyte promoted antibody responses in both trinitrophenyl (TNP)- and PR8-specific B lymphocytes.

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  • T lymphocytes specific for TNP facilitated responses in both TNP- and PR8-specific B lymphocytes.
  • Demonstrated that a single T lymphocyte can collaborate with multiple B lymphocytes possessing distinct antibody receptors.

    • Conclusions:

    • Individual antigen-specific T lymphocytes can collaborate with multiple B lymphocytes, irrespective of their unique antibody receptors.
    • Antigen-specific T cells can independently initiate primary B cell responses in B cells with distinct antigen recognition.
    • Hapten-specific helper T cells can be readily demonstrated and assist B cells recognizing the same or different determinants.