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Interferon immunosuppression: mediation by a suppressor factor.

H M Johnson, J E Blalock

    Infection and Immunity
    |August 1, 1980
    PubMed
    Summary
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    Mouse fibroblast interferon suppresses antibody production by activating suppressor cells in the spleen. These cells release a factor that causes immunosuppression, distinct from interferon's antiviral actions.

    Area of Science:

    • Immunology
    • Cell Biology
    • Virology

    Background:

    • Interferons are known for their antiviral properties.
    • The immunomodulatory effects of interferons are complex and not fully understood.
    • Fibroblast interferon has been observed to impact immune responses.

    Purpose of the Study:

    • To investigate the mechanism by which mouse fibroblast interferon suppresses the in vitro antibody response.
    • To identify the cellular components involved in interferon-induced immunosuppression.
    • To determine if the immunosuppressive mechanism is related to interferon's antiviral activity.

    Main Methods:

    • In vitro antibody response assay using sheep erythrocytes.
    • Induction and isolation of suppressor cells from mouse spleen cells treated with interferon.

    Related Experiment Videos

  • Characterization of the soluble suppressor factor produced by these cells.

    • Main Results:

    • Mouse fibroblast interferon induced suppressor cell activity in spleen cells, leading to suppressed antibody production.
    • A soluble factor produced by these suppressor cells mediated the immunosuppression.
    • The suppressor factor did not exhibit antiviral activity, suggesting a distinct regulatory pathway.

    Conclusions:

    • Interferon regulates B-cell antibody responses through the induction of specific suppressor cells.
    • The immunosuppressive mechanism of interferon is independent of its antiviral effect.
    • This finding reveals a novel pathway for interferon-mediated immune regulation.