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Interferon immunoregulation of antibody response in normal and autoimmune mice is mediated by suppressor T cell
International Archives of Allergy and Applied Immunology
|January 1, 1981
Abstract:
The mechanism through which interferon exerts immunoregulatory influence on antibody production in autoimmune NZB mice and normal Balb/C mice was studied. Interferon suppressed T cell-dependent anti-SRBC response in normal mice indirectly by activating suppressor T cells. The suppressor cell activity by interferon is mediated by Ly123+ cells presumably acting as feedback regulators for the suppression.