Serological cross-reactivity between Sporothrix schenckii and various unrelated fungi

The serological cross-reactivity of Sporothrix schenckii with various unrelated fungi was investigated by use of immunodiffusion tests. A rabbit anti S. schenckii serum was obtained, which reacted with Cladosporium werneckii, C. carrionii, C. bantianum, Coccidioides immitis, Phialophora jeanselmei, P. gougerotii, P. dermatitidis, Fonsecaea pedrosoi, Aspergillus fumigatus, Histoplasma capsulatum and Trichophyton mentagrophytes, but not with Saccharomyces cerevisiae antigens. The serological determinants responsible for the cross-reactions were suggested to be D-galactosyl residues.