Cell composition of granulation tissue in defibrinogenated rabbits

The influence of systemic defibrinogenation on cell composition and capillary formation in sponge-induced early granulation tissue was studied in rabbits. The tissue was studied histologically and the content of RNA, DNA and Hb was determined. Inflammatory cells were identified and quantified using histochemical and biochemical techniques. An accumulation of PMN-leucocytes was found after defibrinogenation whereas the amount of fibroblasts and capillaries was reduced.