Allergic contact dermatitis of the mouse ear

Allergic contact dermatitis to picryl chloride on the mouse ear was registered by measuring the increasing wet weight during the inflammatory reaction. This quantitative technique permitted the use of small experimental groups of regular laboratory mice. Full sensitization to picryl chloride is achieved as early as 3 days after a single painting with the hapten. The allergic reaction peaks at 24 h after challenge. Sensitization and challenge are not inhibited, whether by antihistamine, histamine liberator, or antiserotonin. The hypersensitivity state lasts at least 4 months.