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Polymorphonuclear leukocyte chemotaxis in dermatitis herpetiformis.
Acta Dermato-Venereologica
|January 1, 1981
Summary
Polymorphonuclear leukocyte chemotaxis is not elevated in dermatitis herpetiformis patients. This suggests skin inflammation in dermatitis herpetiformis is not caused by hyper-responsive white blood cells.
Area of Science:
- Immunology
- Dermatology
- Cell Biology
Background:
- Dermatitis herpetiformis is characterized by skin inflammation with neutrophil infiltration.
- The precise mechanisms driving neutrophil accumulation in dermatitis herpetiformis remain incompletely understood.
Purpose of the Study:
- To investigate polymorphonuclear leukocyte (PMN) chemotaxis in patients with dermatitis herpetiformis.
- To determine if increased PMN responsiveness contributes to skin inflammation in this condition.
Main Methods:
- Assessed polymorphonuclear leukocyte (PMN) chemotaxis in 15 dermatitis herpetiformis patients.
- Compared PMN chemotaxis to that of 15 healthy controls.
Main Results:
- No significant difference in polymorphonuclear leukocyte (PMN) chemotaxis was observed between dermatitis herpetiformis patients and healthy controls.
- This indicates that PMN responsiveness to chemotactic factors is not elevated in dermatitis herpetiformis.
Conclusions:
- The accumulation of polymorphonuclear leukocytes (PMNs) in the skin of dermatitis herpetiformis patients is not attributable to an increased intrinsic responsiveness of these cells.
- Findings suggest that factors other than PMN hyper-responsiveness may be responsible for neutrophil recruitment in dermatitis herpetiformis.