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Ethambutol-induced lichenoid eruption.

G Frentz, S Wadskov, V Kassis

    Acta Dermato-Venereologica
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Ethambutol, a tuberculosis drug, can cause a rare lichenoid skin reaction. This reaction, affecting sun-exposed skin, was confirmed in a patient through drug withdrawal and reintroduction.

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    Area of Science:

    • Dermatology
    • Pharmacology
    • Internal Medicine

    Background:

    • Ethambutol is a first-line tuberculostatic agent used to treat tuberculosis.
    • Cutaneous adverse drug reactions to ethambutol are uncommon.
    • Lichenoid drug eruptions are characterized by inflammatory papules and plaques.

    Observation:

    • A 67-year-old male presented with a lichenoid skin eruption.
    • The eruption was localized to areas of the skin exposed to light.
    • The patient was undergoing treatment with ethambutol for tuberculosis.

    Findings:

    • The skin eruption resolved upon withdrawal of ethambutol.
    • Reintroduction of ethambutol led to the recurrence of the eruption, confirming causality.
    • Patch testing with ethambutol at 0.1%, 0.5%, and 1% in aqueous solution yielded negative results.

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    Implications:

    • Ethambutol should be considered as a potential cause of lichenoid photodermatitis.
    • Negative patch test results do not exclude ethambutol-induced cutaneous reactions.
    • Clinicians should maintain a high index of suspicion for drug-induced skin reactions, even with negative patch tests.