Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunoblastic lymphoma: an immunologic study.

J T Prchal, S S Crago, J Mestecky

    Cancer
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Chemokine-adjuvanted electroporated DNA vaccine induces substantial protection from simian immunodeficiency virus vaginal challenge.

    Mucosal immunology·2015
    Same author

    Effects of the once-daily GLP-1 analog liraglutide on gastric emptying, glycemic parameters, appetite and energy metabolism in obese, non-diabetic adults.

    International journal of obesity (2005)·2013
    Same author

    Liraglutide suppresses postprandial triglyceride and apolipoprotein B48 elevations after a fat-rich meal in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled, cross-over trial.

    Diabetes, obesity & metabolism·2013
    Same author

    The once-daily human GLP-1 analogue liraglutide impacts appetite and energy intake in patients with type 2 diabetes after short-term treatment.

    Diabetes, obesity & metabolism·2013
    Same author

    Transferring preterm infants from incubators to open cots at 1600 g: a multicentre randomised controlled trial.

    Archives of disease in childhood. Fetal and neonatal edition·2011
    Same author

    Humoral immune response to keyhole limpet haemocyanin, the protein carrier in cancer vaccines.

    Clinical & developmental immunology·2011
    Same journal

    Long-term outcomes of evolving treatment regimens in Ewing sarcoma survivors diagnosed 1970-1999: A report from the Childhood Cancer Survivor Study.

    Cancer·2026
    Same journal

    Large-scale osteosarcoma sequencing reveals age-associated genomic architectures.

    Cancer·2026
    Same journal

    EZH2 inhibitor tazemetostat voluntarily withdrawn from market.

    Cancer·2026
    Same journal

    Nivolumab and chemotherapy combination approved for previously untreated Hodgkin lymphoma.

    Cancer·2026
    Same journal

    Most older patients with advanced cancer prioritize QOL over extending survival: A secondary analysis of the GAP70+ trial found that among adults aged 70 and older with advanced, noncurable cancer, nearly three-quarters prioritized maintaining QOL.

    Cancer·2026
    Same journal

    Real-world safety, prognostic, and design considerations in ketogenic diet trials for pancreatic cancer.

    Cancer·2026
    See all related articles

    This study presents a case of immunoblastic lymphoma with cold agglutinin hemolytic anemia. The findings suggest a polyclonal B-lymphocyte proliferation, offering insights into lymphoma immunopathogenesis.

    Area of Science:

    • Immunology
    • Hematology
    • Oncology

    Background:

    • Presents an immunologic study of a 59-year-old male patient diagnosed with immunoblastic lymphoma.
    • Details the sudden onset of an uncompensated hemolytic process caused by cold agglutinins shortly after hospital admission.

    Observation:

    • Cold agglutinins exhibited anti-i specificity with low titer at cold temperatures but high thermal amplitude.
    • Immunochemical analysis revealed a polyclonal paraprotein, not a monoclonal one.
    • Peripheral blood, lymph node, and bone marrow analyses showed a majority of plasma cells with cytoplasmic IgG or IgM, indicating polyclonality.

    Findings:

    • Confirmed polyclonality of immunoglobulins through staining with anti-lambda and anti-kappa chain reagents.
    • Observed plasma cells with simultaneous presence of both IgM and IgG, and intercellular free immunoglobulin in lymph node sections.

    Related Experiment Videos

  • The patient's acute hemolysis was managed with plasmapheresis and combination chemotherapy.

    • Implications:

    • Demonstrates evidence of polyclonal B-lymphocyte proliferation in the context of immunoblastic lymphoma.
    • Highlights the potential for complex immunologic responses, including autoimmune hemolytic anemia, in lymphoma patients.
    • Suggests that successful chemotherapy led to sustained remission and normalization of immunoglobulin levels.