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Updated: May 3, 2026
07:26
Ferric Chloride-induced Thrombosis Mouse Model on Carotid Artery and Mesentery Vessel
Published on: June 29, 2015
18.0K
Summary
Thrombocytosis, or high platelet counts, is common in Whipple's disease and resolves with antibiotic treatment. This finding suggests a shared mechanism with other inflammatory gastrointestinal conditions.
Area of Science:
- Gastroenterology
- Hematology
Background:
- Whipple's disease is a rare, chronic bacterial infection.
- Thrombocytosis is an elevation in platelet count, often associated with inflammation.
Purpose of the Study:
- To investigate the occurrence and characteristics of thrombocytosis in patients with Whipple's disease.
- To compare patients with and without thrombocytosis to identify associated factors.
Main Methods:
- Case study of three patients with Whipple's disease and thrombocytosis.
- Retrospective review of 24 published cases of Whipple's disease with recorded platelet counts.
Main Results:
- Three patients presented with severe thrombocytosis (729,000-1,142,000/mm3), which normalized with antibiotic therapy.
- Eleven of 24 patients (46%) had recorded thrombocytosis.
- No significant differences in anemia, marrow infiltration, or classic Whipple's disease symptoms were observed between patients with and without thrombocytosis.
Conclusions:
- Thrombocytosis is a notable finding in Whipple's disease and appears to be a reactive process that improves with treatment.
- The thrombocytosis observed in Whipple's disease shares similarities with that seen in other inflammatory gastrointestinal conditions like celiac sprue, Crohn's disease, and ulcerative colitis.
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