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[Juvenile malignant lymphomas. 2 Non-Hodgkin lymphomas]
Insights
This study on pediatric Non-Hodgkin lymphomas (NHL) found that advanced stages (III-IV) and specific types like Burkitt-type had lower remission rates. Early stages and unclassified lymphoblastic NHL showed better outcomes.
Area of Science:
- Pediatric Oncology
- Hematology
- Immunology
Context:
- Non-Hodgkin lymphomas (NHL) in children present diagnostic and therapeutic challenges.
- Treatment outcomes vary significantly based on disease stage and histological subtype.
- Understanding surface markers aids in classifying and predicting NHL behavior.
Purpose:
- To analyze treatment outcomes for pediatric Non-Hodgkin lymphomas (NHL) based on histological classification and disease stage.
- To correlate histological subtypes (e.g., Burkitt-type, convoluted cell) and Ann Arbor staging with remission rates.
- To evaluate the effectiveness of combined therapy including irradiation, chemotherapy, and surgery.
Summary:
- A cohort of 33 children (ages 2-15) with NHL were treated between 1970-1978.
- Histological classification (Kiel) and surface markers were assessed alongside Ann Arbor staging.
- Therapies included irradiation, chemotherapy, and surgery; 3-year remission rates were 50% for stages I-II and 20% for stages III-IV.
Impact:
- Early-stage pediatric NHL and unclassified lymphoblastic subtypes demonstrated better 3-year remission rates (42%) compared to advanced stages.
- Convoluted cell and Burkitt-type NHL showed poorer prognoses with lower remission rates (16% and 27%, respectively).
- Findings highlight the importance of histological subtype and stage in predicting treatment response for childhood NHL.
Abstract:
Between 1970 and 1978 33 children with Non-Hodgkin-lymphomas at the age of 2-15 years were treated at the university children's hospital of Jena. 27 patients showed the first appearance of the disease, 6 patients had already been treated in other hospitals and were admitted with relapses. The biopsy material was classified or re-classified after the Kiel-classification. Beside the histological classification the surface markers of the malignant cells of NHL-patients were determined. 20 of 33 children were already in stage IV (Ann-Arbor-classification). Among our patients were 6 lymphoblastic NHL of Brukitt type, 10 of the convoluted cell type and 16 unclassified and one lymphoblastic lymphoma. The main localization of the NHL were mediastinum [15] and the gastrointestinal tract [10]. The therapy consisted of irradiation and chemotherapy (2 protocols) and, in case of an abdominal localization, in the attempt at a radical operation. Patients of stage I and stage II showed a complete remission rate of 50 per cent for 3 years; patients of stages III and IV of 20 per cent only. NHL of the convoluted cell type and of the Burkitt-type proved to have worse three-year-remission rates (16 per cent and 27 per cent) than unclassified lymphoblastic NHL (42 per cent).