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Intraventricular administration of rifampin for tuberculous meningitis
Journal of Neurology
|January 1, 1981
Abstract:
A case of tuberculous meningitis associated with cerebral tuberculomas, and resistant to antituberculous therapy is reported. Repeated injections of rifampin, administered through an intraventricular Ommaya drain, provided an effective control of the meningeal infection.
Insights
Tuberculous meningitis with drug-resistant cerebral tuberculomas was treated effectively. Intraventricular rifampin injections via an Ommaya drain controlled the infection.
Area of Science:
- Neurology
- Infectious Diseases
- Microbiology
Background:
- Tuberculous meningitis (TBM) is a severe central nervous system infection.
- Drug resistance complicates TBM treatment, necessitating novel therapeutic strategies.
Observation:
- A patient presented with tuberculous meningitis and multiple cerebral tuberculomas.
- The infection was resistant to standard antitubercular therapies.
Findings:
- Repeated intraventricular injections of rifampin were administered using an Ommaya drain.
- This targeted delivery effectively controlled the meningeal infection and associated tuberculomas.
Implications:
- Intraventricular rifampin may be a viable option for managing refractory TBM with cerebral involvement.
- This case highlights the potential of localized drug delivery in overcoming therapeutic challenges in neurotuberculosis.