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Related Experiment Videos

Evidence that strong Mls determinants are nonpolymorphic.

K L Molnar-Kimber, J Sprent

    Transplantation
    |May 1, 1981
    PubMed
    Summary

    Murine Mls locus gene products trigger strong mixed lymphocyte reactions (MLRs). Experiments reveal that the Mlsa and Mlsd alleles, responsible for potent MLRs, are antigenically identical, suggesting strong Mls determinants are nonpolymorphic.

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    Area of Science:

    • Immunology
    • Genetics

    Background:

    • The murine Mls locus is known to encode gene products that stimulate vigorous primary mixed lymphocyte reactions (MLRs).
    • While the Mls locus is understood to possess four distinct alleles, only two, Mlsa and Mlsd, demonstrably induce strong responses in primary MLRs.

    Purpose of the Study:

    • To investigate the antigenic relationship between the Mlsa and Mlsd alleles of the murine Mls locus.
    • To determine if the determinants responsible for strong MLR responses are polymorphic.

    Main Methods:

    • Experimental analysis of primary mixed lymphocyte reactions (MLRs).
    • Comparative antigenic characterization of Mlsa and Mlsd alleles.

    Main Results:

    • The study demonstrated that the Mlsa and Mlsd alleles are antigenically indistinguishable.
    • This finding indicates that the strong Mls determinants are nonpolymorphic.

    Conclusions:

    • The strong Mls determinants, Mlsa and Mlsd, are functionally equivalent and antigenically identical.
    • Contrary to initial assumptions of polymorphism, strong Mls determinants exhibit a nonpolymorphic nature.

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