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Itch following photochemotherapy for psoriasis
Acta Dermato-Venereologica
|January 1, 1981
Summary
Psoriasis patients treated with 8-methoxypsoralen and UVA (PUVA) experienced increased nocturnal scratching and limb movement due to itch. Dithranol treatment showed minimal changes in nocturnal activity for psoriasis patients.
Area of Science:
- Dermatology
- Phototherapy
- Pharmacology
Background:
- Psoriasis is a chronic inflammatory skin condition characterized by intense itching (pruritus).
- Nocturnal scratching significantly impacts patient quality of life.
- Quantitative assessment of itch is crucial for evaluating treatment efficacy.
Purpose of the Study:
- To quantitatively compare the effects of 8-methoxypsoralen and UVA (PUVA) versus dithranol on nocturnal itch in psoriasis patients.
- To assess the impact of these treatments on nocturnal limb movements as an indicator of itch and restlessness.
Main Methods:
- 12 patients with psoriasis received 8-methoxypsoralen and UVA (PUVA) therapy.
- 7 patients with psoriasis received dithranol therapy.
- Nocturnal scratching and limb movements were quantitatively measured to assess itch.
Main Results:
- Three patients undergoing PUVA therapy exhibited increased nocturnal limb movement, primarily attributed to itch.
- A partial contribution of restlessness to increased limb movement was observed in some PUVA-treated patients.
- Dithranol treatment resulted in minimal alterations in nocturnal limb movement.
Conclusions:
- PUVA therapy may exacerbate nocturnal itch and restlessness in some psoriasis patients.
- Dithranol appears to have a less pronounced effect on nocturnal itch compared to PUVA.
- Further research is needed to elucidate the mechanisms behind PUVA-induced nocturnal symptoms.