The role of interferon in immediate hypersensitivity and autoimmune diseases

We have presented evidence showing that interferon can enhance the IgE-mediated release of histamine. We have also shown that immune interferon is present in the circulation of patients with certain autoimmune diseases. Furthermore, there is a positive correlation between active systemic lupus erythematosus and interferon levels. Systemic lupus erythematosus is characterized by immune hyperactivity. The continuous presence of type II, immune interferon in the circulation of these patients may, on one hand, contribute to the immunological aberrations, while on the other hand, protect against viral infections. At the present time we are looking for interferon in the circulation of patients with other autoimmune disorders.