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Related Experiment Videos

Stilboestrol toxicity in a dog.

J N Mills, D H Slatter

    Australian Veterinary Journal
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Stilboestrol dipropionate treatment for canine prostatic hyperplasia caused severe toxicity, leading to marrow aplasia and death. This case highlights the critical risks of synthetic estrogen use in veterinary medicine.

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    Area of Science:

    • Veterinary Medicine
    • Toxicology
    • Canine Health

    Background:

    • Prostatic hyperplasia is common in older male dogs.
    • Stilboestrol dipropionate, a synthetic estrogen, has been used to manage canine prostatic hyperplasia.
    • Estrogen therapy in dogs carries potential risks, including bone marrow suppression.

    Observation:

    • A dog with prostatic hyperplasia received stilboestrol dipropionate (10 mg daily for 5 days).
    • The dog developed anemia and thrombocytopenia by day 11.
    • Significant leukocytosis was observed on day 15, followed by a sharp decline in white blood cell count.

    Findings:

    • The canine patient exhibited severe hematological abnormalities, including anemia, thrombocytopenia, and marked fluctuations in white blood cell count.

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  • Concurrent peritonitis and prostatitis/cystitis were treated with antibiotics.
  • The dog ultimately succumbed to marrow aplasia on day 41.

    • Implications:

    • This case underscores the significant toxicity associated with stilboestrol dipropionate in dogs.
    • It highlights the potential for severe, life-threatening adverse effects like bone marrow aplasia.
    • Veterinary practitioners should exercise extreme caution and consider safer alternatives for managing prostatic hyperplasia.