Suppressive effects of surgical stress on circulating androgens during and after prostatectomy

Changes in circulating testosterone (T) and dihydrotestosterone (DHT) levels were investigated 2 days before and 2, 7, 30 and 60 days after retropubic prostatectomy in 28 patients with benign prostatic hypertrophy. Following operation the concentrations of both steroids declined and reached minimal levels 2 days after surgery. One month post-operatively testosterone had recovered to its pre-operative value, whilst the recovery of dihydrotestosterone to its pre-operative level required a minimum period of 2 months. These data indicate the need for careful interpretation of any androgen measurement following surgery.