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Related Experiment Videos

Postocclusive cutaneous vasodilatation mediated by substance P.

F Lembeck, J Donnerer

    Naunyn-Schmiedeberg'S Archives of Pharmacology
    |April 1, 1981
    PubMed
    Summary

    Reactive hyperemia, a form of vasodilation after arterial occlusion, is neurogenically mediated by substance P release from small nerve fibers. This mechanism also underlies the axon reflex.

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    Area of Science:

    • Neuroscience
    • Physiology
    • Pharmacology

    Background:

    • Reactive hyperemia, or postocclusive cutaneous vasodilation, is a physiological response to temporary arterial occlusion.
    • The precise mechanisms underlying reactive hyperemia, particularly the role of neurogenic factors, require further elucidation.

    Purpose of the Study:

    • To investigate the neurogenic mechanisms responsible for reactive hyperemia in the rat hind paw.
    • To identify the specific neuropeptides involved in mediating this vasodilatory response.

    Main Methods:

    • Studied reactive hyperemia in rat hind paws following arterial occlusion.
    • Utilized chronic denervation and capsaicin pretreatment to assess neurogenic involvement.
    • Investigated the role of histamine via depletion with compound 48/80.
    • Examined the effects of infused neuropeptides, including substance P and vasoactive intestinal polypeptide.

    Main Results:

    • Postocclusive vasodilation was significantly reduced (>60%) by denervation and capsaicin, indicating a neurogenic origin mediated by small afferent fibers.
    • Histamine depletion reduced the vasodilatation, suggesting histamine's involvement.
    • Substance P, but not vasoactive intestinal polypeptide, mimicked the reactive hyperemia response in terms of vasodilation and plasma extravasation.
    • Substance P demonstrated significantly higher vasodilator potency than vasoactive intestinal polypeptide.

    Conclusions:

    • The study concludes that postocclusive cutaneous vasodilation is primarily mediated by the release of substance P from peripheral nerve endings.
    • The findings suggest that the axon reflex, known to involve neurogenic vasodilation, operates through a similar substance P-mediated mechanism.

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