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Related Experiment Videos

Histamine release by sugar polymers in the rat.

G B West

    Agents and Actions
    |April 1, 1981
    PubMed
    Summary

    Insulin enhances histamine release from rat peritoneal mast cells, independent of blood sugar levels. This suggests a direct insulin effect on mast cells, even in diabetic rats, and is inhibited by disodium cromoglycate.

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    Area of Science:

    • Immunology
    • Endocrinology
    • Pharmacology

    Background:

    • Insulin is a key metabolic hormone.
    • Mast cells are involved in inflammatory responses.
    • Sugar polymers like dextran can induce histamine release.

    Purpose of the Study:

    • To investigate the effect of insulin on histamine release induced by sugar polymers.
    • To determine if insulin's effect is mediated by changes in blood sugar levels.
    • To explore the direct action of insulin on peritoneal mast cells.

    Main Methods:

    • Intraperitoneal injections of dextran or dextrin in rats.
    • Administration of insulin simultaneously with sugar polymers.
    • Monitoring blood sugar levels.
    • Observation of histamine release.
    • Experiments conducted in both normal and diabetic rats.
    • Inhibition studies using disodium cromoglycate.

    Main Results:

    • Insulin potentiated histamine release induced by sugar polymers.
    • This potentiation occurred irrespective of changes in blood sugar levels.
    • Insulin's effect was observed in diabetic rats.
    • Disodium cromoglycate inhibited the potentiation effect.

    Conclusions:

    • Insulin directly affects peritoneal mast cells in vivo.
    • Hypoglycemia is not the mechanism behind insulin's potentiation of histamine release.
    • Insulin's action on mast cells may play a role in inflammatory processes.

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