[Effect of metformin on plasma lipoprotein lipase]

The action of metformin with respect to in vitro turbidimetric clarification of a glyceridic system (lipostrate) has been studied in a group of metabolically healthy subjects. It is observed that biguanide associated with 3GS, heparinoid with known structure and costant liposemec activity, significantly accentuates clarifying activity whereas biguanide alone leads to only a slight increase in the clarification index, at least 5 times less than that induced by 3GS. Results are discussed. These agree with some recent experiments on the catabolic and antiatherogenic effect in vivo of biguanide on the VLDL and LDL, fostering their conversion into high density lipoproteins.