[Effects of aprotinin on the endochondral ossification process in growing rabbits]

Present study demonstrated that aprotinin, a natural inhibitor of proteases, interfered with the ossification process of epiphyseal and metaphyseal cartilages of growing rabbits. This biological effect may be induced by inhibition of tissue proteases, that acts on cartilage matrix to produce a substance which is an important component of the calcifying mechanism during enchondral ossification.