Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Generation of immune specificity: a working hypothesis.

A Danchin, P P Slonimski

    Bio Systems
    |January 1, 1981
    PubMed
    Summary

    This study proposes a speculative model for how the immune system generates specificity. It suggests combinatorial splicing of pre-mRNA could create diverse immunoglobulins, potentially involving the nuclear envelope.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The calmodulin-sensitive adenylate cyclase of Bordetella pertussis: cloning and expression in Escherichia col.

    Molecular microbiology·2017
    Same author

    Escherichia coli molecular genetic map (1000Kbp):update.

    Molecular microbiology·2017
    Same author

    Bacillus subtilis genome project: cloning and sequencing of the 97 kb region from 325° to 333deg.

    Molecular microbiology·2017
    Same author

    [On the conversion of the ad-3 gene in yeast].

    Comptes rendus des seances de la Societe de biologie et de ses filiales·2014
    Same author

    Mitochondrial and nuclear mitoribosomal suppressors that enable misreading of ochre codons in yeast mitochondria : I. Isolation, localization and allelism of suppressors.

    Current genetics·2013
    Same author

    Mitochondrial and nuclear mitoribosomal suppressors that enable misreading of ochre codons in yeast mitochondria : II. Specificity and extent of suppressor action.

    Current genetics·2013

    Area of Science:

    • Immunology
    • Molecular Biology
    • Epigenetics

    Background:

    • The generation of immune specificity, particularly the diversity of immunoglobulins, is a complex biological process.
    • Current models primarily focus on genetic mechanisms for antibody diversity.

    Purpose of the Study:

    • To present a speculative model for the epigenetic generation of immune specificity.
    • To propose a novel mechanism involving combinatorial splicing and the nuclear envelope for immunoglobulin diversity.

    Main Methods:

    • Theoretical model development.
    • Justification of postulates based on existing biological principles.
    • Discussion of experimental implications.

    Main Results:

    • A speculative model is presented where combinatorial splicing of a single pre-mRNA molecule generates diverse messenger RNAs (mRNAs).
    • The model postulates a unique role for the nuclear envelope in translating intron sequences into messenger maturation proteins.

    Conclusions:

    • Epigenetic mechanisms, such as combinatorial splicing, may contribute to the generation of immune specificity.
    • The nuclear envelope could play a critical role in the synthesis of diverse immunoglobulins.

    Related Experiment Videos