Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Evaluation of multiple regimens in leprosy.

G Ramu, Sreevatsa, U Sengupta

Leprosy in India

|April 1, 1981

Summary

Leprosy patients showed reduced bacillary load with treatment. Dapsone combined with rifampicin (DDS + RIF) was most effective in clearing Mycobacterium leprae from the blood compared to other drug regimens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genomic characterization of Mycobacterium lepromatosis from ENL patients from India.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2023

Same author

Analysis of bacteriological Index between fixed multidrug therapy and new WHO recommended alternative regimen with ofloxacin, minocycline and clofazimine of rifampicin resistant cases from the hospitals of The Leprosy Mission, India.

Journal of global antimicrobial resistance·2020

Same author

Survival of Mycobacterium leprae and association with Acanthamoeba from environmental samples in the inhabitant areas of active leprosy cases: A cross sectional study from endemic pockets of Purulia, West Bengal.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases·2019

Same author

Effect of Prothionamide on the Infectivity of Lepromatous Leprosy.

Indian journal of dermatology, venereology and leprology·2017

Same author

Ten-year Study of Lepromin Response in Child Contacts of Leprosy Patients.

Indian journal of dermatology, venereology and leprology·2017

Same author

Presence of viable Mycobacterium leprae in environmental specimens around houses of leprosy patients.

Indian journal of medical microbiology·2016

Area of Science:

Medical Microbiology
Infectious Diseases
Dermatology

Background:

Leprosy, caused by Mycobacterium leprae, remains a global health concern.
Bacteraemia is a significant indicator of disease activity and treatment response in leprosy.

Purpose of the Study:

To evaluate the efficacy of different antileprosy drug regimens in clearing Mycobacterium leprae from the bloodstream.
To compare the impact of dapsone monotherapy versus combination therapies on bacteraemia in lepromatous leprosy.

Main Methods:

Weekly assessment of bacteraemia in 36 lepromatous leprosy patients.
Patients received one of four regimens: dapsone alone (DDS), DDS + rifampicin (RIF), DDS + clofazimine (CLF), or DDS + thiacetazone (TCT).
Bacteriological index (BI) of skin lesions was monitored concurrently.

Main Results:

Overall, treatment led to a considerable decrease in bacillary load in the blood.
Skin bacteriological index remained relatively constant throughout the study period.
Dapsone + rifampicin (DDS + RIF) demonstrated superior efficacy in clearing acid-fast bacilli (AFB) from blood compared to other regimens.
No significant difference in M. leprae clearance from blood was observed between DDS alone and DDS + CLF or DDS + TCT groups.

Conclusions:

Combination therapy with DDS + RIF is highly effective for reducing bacteraemia in lepromatous leprosy.
Monitoring blood bacillary load is crucial for assessing treatment effectiveness.
Further research into optimal combination therapies for leprosy is warranted.

Related Experiment Videos