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[Modification of the thrombocyte function using hormonal contraception. 2. Platelet adhesiveness,
Zentralblatt Fur Gynakologie
|January 1, 1976
Summary
Oral contraceptives like Ovosiston significantly increase platelet adhesiveness and alter thrombelastographic values. These changes in platelet function suggest an elevated risk of thromboembolism in women using this anticonceptive agent.
Area of Science:
- Hematology
- Pharmacology
- Thrombosis Research
Context:
- Investigated the hemostatic effects of Ovosiston, an oral contraceptive agent.
- Focused on platelet function and coagulation parameters in women using Ovosiston.
Purpose:
- To assess the impact of Ovosiston on platelet adhesiveness.
- To evaluate thrombelastographic changes associated with Ovosiston use.
- To determine the potential risk of thromboembolism linked to Ovosiston.
Summary:
- Observed a significant increase in platelet adhesiveness in 102 women treated with Ovosiston.
- Detected significant variations in thrombelastographic investigations, indicating altered coagulation dynamics.
- Abnormalities in platelet function and thrombelastographic values suggest Ovosiston influences hemostasis.
Impact:
- Findings indicate that Ovosiston may enhance the risk of thromboembolism.
- Highlights the importance of considering hemostatic effects when prescribing oral contraceptives.
- Suggests further research into the prothrombotic potential of Ovosiston and similar agents.