Peripapillary subretinal neovascularization in presumed sarcoidosis

Peripapillary subretinal neovascularization developed in both eyes of two young women with bilateral chronic granulomatous uveitis. Despite intensive medical therapy, central vision was lost in two eyes owing to disciform scarring that extended to the macula. The neovascularization in the other two eyes was treated successfully with argon laser photocoagulation. Neither of the patients had the clinical or roentgenographic findings typical of sarcoidosis. Both, however, showed elevated serum angiotensin-converting enzyme activity, which provides indirect evidence for the diagnosis of sarcoid uveitis.