Modulation of proprioceptive transcortical reflexes in the cat with a penicillin epileptic motor focus

Mechanisms responsible for the triggering of paroxysmal events by proprioceptive afferents, previously described in the monkey with a chronic epileptic focus, were studied in more detail in the cat with a penicillin focus. To analyse the topical organization of this reflex triggering, the focus was restricted to very small areas of the motor cortex; in this study only pericruciate areas were considered in which stimulation elicited a motor response in one of the several forelimb muscles tested, and which received afferents from that muscle. When the focus was located in the post-sigmoid gyrus, stimulation (usually by stretch) of the given (target) muscle first elicited a cortical spike following the evoked response, and secondly a late phasic EMG response (about 40 msec latency) quite distinct from purely spinal reflexes. Cortical spikes and late EMG responses were closely correlated, especially considering their probability of occurrence or their parallel latency fluctuations. In most cases, this effect was limited to the muscle whose motor area had been treated with penicillin: stretching muscles in the vicinity was ineffective, nor were these muscles activated when the target muscle was stimulated. Evidence is given for the participation of a transcortical reflex in the generation of the late phasic response and for the involvement of the pyramidal tract in this reflex.