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Related Experiment Videos

Neuropeptides in striato-nigral pathways.

A C Cuello, M Del Fiacco, G Paxinos

    Journal of Neural Transmission
    |January 1, 1981
    PubMed
    Summary

    This study confirms a Leu-enkephalin pathway between the neostriatum and globus pallidus. It also identifies substance P in substantia nigra nerve terminals, detailing their synaptic connections.

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    Area of Science:

    • Neuroscience
    • Neuroanatomy

    Background:

    • The neostriatum and globus pallidus are key components of the basal ganglia motor system.
    • Neuronal pathways within the basal ganglia are crucial for motor control and function.

    Purpose of the Study:

    • To confirm the existence of a Leu-enkephalin pathway connecting the neostriatum and globus pallidus.
    • To investigate the presence and synaptic organization of substance P in the substantia nigra.

    Main Methods:

    • Immunohistochemistry was employed to visualize Leu-enkephalin and substance P.
    • Neurotoxic agents (kainic acid, colchicine) and knife lesions were used to delineate neuronal pathways.
    • Electron microscopy was utilized to examine synaptic connections of substance P-containing terminals.

    Main Results:

    • A Leu-enkephalin pathway from the neostriatum to the globus pallidus was confirmed.
    • Substance P was localized to nerve terminals in the substantia nigra.
    • Electron microscopy revealed substance P-positive terminals forming both symmetric and asymmetric synapses, primarily on dendritic profiles.

    Conclusions:

    • The study provides anatomical evidence for a Leu-enkephalin pathway in the basal ganglia.
    • Substance P is present in nigral neurons and forms synaptic connections within the substantia nigra.
    • These findings contribute to understanding peptide-containing pathways in the nigro-striatal system.

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