Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Screening of solid and porous materials for pacemaker electrodes.

M S Hirshorn, L K Holley, J R Hales

    Pacing and Clinical Electrophysiology : PACE
    |July 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Tracking ultrafast hot-electron diffusion in space and time by ultrafast thermomodulation microscopy.

    Science advances·2019
    Same author

    Supplementation of collagen scaffolds with SPARC to facilitate mineralization.

    Journal of biomedical materials research. Part B, Applied biomaterials·2012
    Same author

    Injectable hydrogel materials for spinal cord regeneration: a review.

    Biomedical materials (Bristol, England)·2012
    Same author

    Cell response to collagen-calcium phosphate cement scaffolds investigated for nonviral gene delivery.

    Journal of materials science. Materials in medicine·2011
    Same author

    Isolation and in vitro proliferation of chondrocytes, tenocytes, and ligament cells.

    Methods in molecular medicine·2011
    Same author

    Direct Measurement of Venous Pressure in Man.

    Canadian Medical Association journal·2010

    Porous titanium alloy electrodes showed better attachment and lower sensing impedance in pacemaker studies. Other tested materials like titanium, carbon, and silver had acceptable electrical properties but no threshold reduction.

    Area of Science:

    • Biomaterials Science
    • Medical Device Engineering
    • Cardiovascular Research

    Background:

    • Pacemaker lead dislodgement and tissue reaction are clinical challenges.
    • Optimizing electrode materials is crucial for long-term pacemaker function.

    Purpose of the Study:

    • To evaluate various materials for pacemaker electrode tips.
    • To assess electrical properties and tissue response of different electrode materials.

    Main Methods:

    • Implantation of pacemaker leads in sheep for up to one year.
    • In vivo electrical measurements and post-mortem histopathological examination.
    • Comparison of platinum, titanium, carbon, silver, zinc, and porous titanium alloy electrodes.

    Main Results:

    Related Experiment Videos

    • Titanium, carbon, and silver showed acceptable electrical characteristics but did not reduce chronic stimulation thresholds compared to platinum.
    • Zinc electrodes induced severe tissue reactions and high stimulation thresholds.
    • Porous titanium alloy electrodes exhibited reduced dislodgement, improved attachment, and lower sensing impedance.

    Conclusions:

    • Porous titanium alloy electrodes offer significant advantages for pacemaker lead applications.
    • Material selection critically impacts lead stability, tissue response, and electrical performance.
    • Further research into advanced electrode materials is warranted for enhanced pacing therapy.