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[Human interferons -- features and chances (author's transl)].

A Pohl, K Moser, M Micksche

    Wiener Klinische Wochenschrift
    |July 10, 1981
    PubMed
    Summary
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    Interferons are crucial antiviral and immunomodulatory proteins. While showing promise in treating viral infections and tumors, their therapeutic effectiveness requires further study with purified, economically viable preparations.

    Area of Science:

    • Immunology
    • Virology
    • Cell Biology

    Context:

    • Interferons are cellular products with diverse biological activities.
    • They play a key role in antiviral defense and immune regulation.
    • Immune interferon is involved in cellular immune responses against infections and tumors.

    Purpose:

    • To summarize the known functions and potential therapeutic applications of interferons.
    • To highlight the limitations of current research due to interferon scarcity and impurity.

    Summary:

    • Interferons confer viral resistance, inhibit cell proliferation, and modulate immune functions like phagocytosis and natural killer cell activity.
    • In viral infections, they inhibit viral replication and activate cellular immunity to eliminate infected cells.

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  • Immune interferon reduces cell multiplication and recruits cytotoxic cells for tumor and injury abrogation.

    • Impact:

    • Clinical trials suggest potential effectiveness against chronic viral infections and tumors.
    • Current results are inconclusive due to limited availability and purity of human interferon.
    • Further controlled studies with purified interferon are needed to establish therapeutic efficacy and economic feasibility.