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Histamine release from human right atrium.

R W Gristwood, J C Lincoln, D A Owen

    British Journal of Pharmacology
    |September 1, 1981
    PubMed
    Summary
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    Compound 48/80 triggers histamine release from human atrial tissue, impacting heart function. Cimetidine blocks this effect, indicating mast cell degranulation

    Area of Science:

    • Cardiovascular Physiology
    • Pharmacology
    • Histamine Biology

    Background:

    • Human atrial tissue contains significant histamine levels.
    • Compound 48/80 is known to induce histamine release.
    • Mast cells are present in atrial tissue and can degranulate.

    Purpose of the Study:

    • To investigate histamine release from human atrial samples.
    • To determine the functional effects of compound 48/80 on atrial contractility.
    • To assess the role of histamine in mediating these effects.

    Main Methods:

    • Human right atrial biopsy samples were used.
    • Samples were exposed to compound 48/80.
    • Electrical pacing and force of contraction measurements were performed.

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  • Cimetidine was used as a pretreatment to block histamine receptors.

    • Main Results:

    • Compound 48/80 induced significant histamine release from atrial tissue.
    • Exposure to compound 48/80 increased the force of atrial contraction.
    • Cimetidine pretreatment abolished the inotropic response to compound 48/80.

    Conclusions:

    • Mast cell degranulation in human atria releases sufficient histamine to alter cardiac function.
    • Histamine plays a role in modulating atrial contractility.
    • This finding has implications for understanding cardiac responses to inflammatory mediators.