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Related Experiment Videos

Hydroxyethyl starch.

W L Thompson

    Developments in Biological Standardization
    |January 1, 1980
    PubMed
    Summary
    This summary is machine-generated.

    Hydroxyethyl starch (HES) products, like HES-70/70 and HES-50/50, offer effective plasma volume expansion. These colloids demonstrate comparable efficacy to albumin, with varying excretion rates and minimal adverse effects.

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    Area of Science:

    • Biochemistry
    • Pharmacology
    • Colloid Science

    Background:

    • Hydroxyethyl starch (HES) products are critical for plasma volume expansion.
    • Designation requires molecular weight and molar substitution ratios for efficacy.
    • HES-70/70 and HES-50/50 are key examples with distinct properties.

    Purpose of the Study:

    • To compare the efficacy and kinetics of HES products with human albumin and dextran-40.
    • To evaluate the safety and adverse effects of HES administration.
    • To explore the potential for tailored HES formulations.

    Main Methods:

    • Comparative analysis of plasma volume expansion and colloidal activity.
    • Assessment of extravasation and elimination rates in subjects.
    • Monitoring of adverse reactions, including anaphylactoid responses and coagulation effects.

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    Main Results:

    • HES-70/70 is equivalent to human albumin in plasma volume expansion and colloidal activity.
    • HES-50/50 shows efficacy similar to dextran-40 but with faster elimination and no accumulation.
    • Adverse reactions to HES were infrequent and mild; no significant hyperviscosity or urine flow reduction observed.

    Conclusions:

    • HES products, particularly HES-70/70 and HES-50/50, are effective plasma volume expanders with a favorable safety profile.
    • Tailoring HES by modifying molecular size and hydrolysis rates allows for controlled drug kinetics for specific applications.
    • Hydroxyethylation of starches provides safe colloids with adjustable pharmacological effects.