[Study of the effect of dioxidine on the subcellular fractions of microbial cells]

Penetration of dioxidine to the cells of Staphylococcus aureus and the drug effect on subcellular fractions were examined. High pressure liquid chromatography demonstrated that after penetration to the cells of Staphylococcus aureus dioxidine was found unchanged in the cytoplasmic fraction. Differences were disclosed in the biochemical action pattern of the drug on the growing and stationary culture. Exposure of the growing culture to dioxidine resulted in an appreciable decrease in the protein and especially in nucleic acid levels, in significant changes in the composition of the intracellular protein complex. The drug produced structural alterations within the cell wall. These alterations increased with concentrations and were characterized by the loosening of the wall and by the membrane release.