[Influenza virus sensitivity to interferon and its inducer]

Area of Science:

• Virology
• Immunology

Background:

• Interferons are crucial antiviral proteins.
• Influenza viruses exhibit varied responses to antiviral agents.

Purpose of the Study:

• To assess influenza virus sensitivity to human and chicken interferons.
• To evaluate the role of poly(G)•poly(C) as an interferon inducer.

Main Methods:

• Testing sensitivity of influenza virus strains to interferons.
• Utilizing poly(G)•poly(C) to induce interferon production.
• Analyzing parent and recombinant influenza virus sensitivity.

Main Results:

• Demonstrated differential sensitivity of human and animal influenza viruses to interferon.
• Established a correlation between sensitivity to poly(G)•poly(C)-induced interferon and chicken interferon.
• Showed that recombinant viruses inherited interferon sensitivity from parental strains.

Conclusions:

• Influenza virus sensitivity to interferon is a variable trait.
• Poly(G)•poly(C)-induced interferon response is linked to chicken interferon sensitivity.
• Interferon sensitivity is genetically determined by parental strains in recombinants.