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Updated: Aug 10, 2026

From a 2DE-Gel Spot to Protein Function: Lesson Learned From HS1 in Chronic Lymphocytic Leukemia
Published on: October 19, 2014
Abstract:
When reassessing the clonal origin of malignant tumors, it is argued that most malignant tumors are heterogeneous for a number of phenotypic characteristics including antigenicity. Taking the murine AkR leukemia as an example, how antigenic heterogeneity may affect immunologic approaches to diagnostics and treatment of leukemias is discussed. The consequences for use of monoclonal antibodies in relation to human leukemias are also discussed, especially in light of recent achievements in producing human monoclonal antibodies.
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