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Related Experiment Videos

Interactions between developing autonomic neurons and their target tissues.

I A Hendry, C E Hill, R E Bonyhady

    Ciba Foundation Symposium
    |January 1, 1981
    PubMed
    Summary

    Target tissues release neurotrophic factors, called retrophins, essential for neuron survival. Researchers identified nerve growth factor for sympathetic neurons and a distinct factor for parasympathetic neurons.

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    Area of Science:

    • Neuroscience
    • Developmental Biology
    • Cell Biology

    Background:

    • Neurons require target tissue contact for survival and maturation.
    • Target tissues release neurotrophic factors (retrophins) that support neuron survival via retrograde transport.
    • Nerve growth factor is a known retrophin for the sympathetic nervous system.

    Purpose of the Study:

    • To identify the retrophin responsible for parasympathetic neuron survival.
    • To investigate the mechanisms of neurotrophic factor transport in the autonomic nervous system.

    Main Methods:

    • Culturing target tissues with radiolabeled amino acids to identify retrogradely transported proteins.
    • Testing the retrograde transport of a purified neurotrophic factor for the chick ciliary ganglion by parasympathetic neurons.

    Main Results:

    • Proteins synthesized and released by target tissues were found to be retrogradely transported by parasympathetic neurons.
    • A purified neurotrophic factor for the chick ciliary ganglion demonstrated retrograde transport by parasympathetic neurons.
    • Evidence suggests at least two distinct retrophins exist within the autonomic nervous system.

    Conclusions:

    • Nerve growth factor serves as the retrophin for the sympathetic nervous system.
    • A separate, yet unidentified, retrophin supports parasympathetic neuron development.
    • These findings highlight the differential regulation of neuronal survival within the autonomic nervous system.

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