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[Rhythmographic study of the frequency dependence of extrasystole in ischemic heart disease]
Kardiologiia
|October 1, 1981
Insights
Premature beats in chronic ischemic heart disease often depend on heart rate. Antiarrhythmic drugs were less effective when this rate dependence was absent in patients.
Area of Science:
- Cardiology
- Cardiac Electrophysiology
- Clinical Research
Context:
- Chronic ischemic heart disease (IHD) is a significant cause of morbidity and mortality.
- Premature beats (extrasystoles) are common in IHD patients and can impact prognosis.
- Understanding factors influencing extrasystole frequency is crucial for effective management.
Purpose:
- To investigate the frequency dependence of extrasystoles in patients with chronic IHD.
- To evaluate the antiarrhythmic effect of specific drugs in relation to extrasystole frequency dependence.
Summary:
- A rhythmographic study analyzed extrasystole frequency at rest, orthostasis, and during exercise in 236 chronic IHD patients.
- Frequency dependence of extrasystoles was observed in 75.4% of the studied patients.
- Novocainamide, propranolol, and atropine showed a less pronounced antiarrhythmic effect when extrasystole frequency dependence was absent.
Impact:
- Findings suggest that the presence or absence of extrasystole rate dependence influences the efficacy of certain antiarrhythmic medications.
- This highlights the importance of assessing rate dependence for personalized antiarrhythmic therapy in IHD.
- Provides insights into the pathophysiology of arrhythmias in chronic IHD.
Abstract:
Results are given of the rhythmographic study of the frequency of extrasystole at rest, in the orthostatic position and during exercise in 236 patients with chronic ischaemic disease of the heart. The frequency dependence of extrasystole (the rate dependence of premature beats) was seen in 75.4% of cases. In the absence of the rate dependence of extrasystole, novocainamide, propranolol and atropine exerted marked antiarrhythmic effect less frequently than when such a dependence was present.